This new injectable gel looks like toothpaste; the gel consists of a mixture of oppositely charged nanoparticles that attract each other; this keeps the gel intact and prevents the particles from drifting away. Each nanoparticle in the gel consists of spheres of dextrin loaded with an enzyme which helps in converting glucose into gluconic acid.
The pharmacological mechanism behind this new injectable is when sugar levels are high in the body, the enzymes in the nanogel produce large quantities of gluconic acid that creates an acidic environment, and this causes the dextrin sphere to disintegrate and release insulin. The research was first conducted on mice with type 1 diabetes, and it was observed that one injection maintains the normal blood sugar level for an average of ten days.
Further research is going on this injectable nanogel to respond even more quickly to the high sugar levels. They want this nanogel to act as pancreas islet cells. The researchers are planning to further prove this delivery system, before testing the particles in humans, reported Mumbai Mirror.
The most popular citizen journalists' reports on merinews chosen automatically on the basis of views and comments