Fasting is often inconvenient for patients and discourages compliance with routine screening programs.
On the other hand, eating before a cholesterol test can highlight insulin resistance, which is associated with worse post meal lipid clearance. High triglyceride levels after eating are predictors of insulin resistance. Total and good HDL cholesterol values do not change with food.
Current guidelines suggest that blood samples for lipid profiles should be obtained after a 9 to 12-hour fast. This requirement is not always practical for patients, who rarely present in a fasting state.
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