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Be cautious in giving painkiller to patients with high cholesterol
Dr KK Aggarwal | 17 Sep 2012

Long-term non-steroidal anti-inflammatory painkiller drugs (NSAIDs) such as naproxen should not be prescribed to patients with high cholesterol.

IN A swine model study published in Surgery Dr Frank Sellke, chief of cardiothoracic surgery and research at Rhode Island Hospital found that a high-cholesterol diet reduced blood flow to the heart muscle in animal models with chronic heart disease when given daily naproxen. They also found reduced levels of prostacyclin, a compound that dilates blood vessels and prevents blood clots.

These findings suggest that there may be a stronger risk of negative effects on the heart in patients who have high cholesterol levels and are taking NSAIDs as a form of pain or inflammation relief.