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Combo drugs best for lowering blood pressure
Dr KK Aggarwal | 19 Jan 2012

A low-dose four-drug combination is more effective for reducing high blood pressure than treatment with a high dose of a single drug, said Padmashri & Dr. B.C. Roy National Awardee, Dr. KK Aggarwal, President, Heart Care Foundation of India.

A LOW-dose four-drug combination is more effective for reducing high blood pressure than treatment with a high dose of a single drug, said Padmashri & Dr. B.C. Roy National Awardee, Dr. KK Aggarwal, President, Heart Care Foundation of India.
Quoting an irish study published in the journal Hypertension, Dr. Aggarwal said that most people with high blood pressure need two to three antihypertensive drugs.
Combining low doses of established antihypertensive medicines in one or two drugs can produce better blood pressure control than full doses of individual drugs.In the study doctors from Dublin, investigated this approach by studying 108 untreated, hypertensive patients. The subjects were randomly allocated to take one of four agents -- a calcium channel blocker, a beta-blocker, a diuretic, or an ACE inhibitor -- or a capsule containing all four drugs at one quarter of the dose used for single-drug therapy.http://hcfi.emedinews.in/
After 4 weeks, the reduction in pressure with the combination treatment was 19 points, significantly greater than the 6 to 11 points seen with the various individual agents.
In the study  60% of combination-drug patients achieved a normal blood pressure reading compared with  15 –45% of patients taking individual drugs.
The combination approach, has the potential to reduce costs, with possibly fewer side effects, and the number of medicines to be taken each day.